THK01

产品说明书

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Chemical Structure| 2226941-26-8 同义名 : -
CAS号 : 2226941-26-8
货号 : A2021568
分子式 : C20H13N3O2
纯度 : 98%+
分子量 : 327.33
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 THK01 serves as a potent ROCK2 inhibitor with IC50 values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. It inhibits breast cancer metastasis through the ROCK2-STAT3 signaling pathway and is useful for breast cancer research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.28mL

3.06mL

1.53mL

30.55mL

6.11mL

3.06mL
参考文献

[1]Wang J, et, al. Discovery of unglycosylated indolocarbazoles as ROCK2 isoform-selective inhibitors for the treatment of breast cancer metastasis. Eur J Med Chem. 2023 Mar 15;250:115181.