ARV-766

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Chemical Structure| 2750830-09-0 同义名 : Luxdegalutamide
CAS号 : 2750830-09-0
货号 : A2005058
分子式 : C45H54FN7O6
纯度 : 98%
分子量 : 807.95
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(129.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ARV-766 is identified as an orally available and potent PROTAC that targets the degradation of both the wild-type androgen receptor (AR) and key AR LBD mutants, specifically the prevalent AR L702H, H875Y, and T878A mutations[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.24mL

0.25mL

0.12mL

6.19mL

1.24mL

0.62mL

12.38mL

2.48mL

1.24mL
参考文献

[1]Petrylak D P, et al. A phase 2 expansion study of ARV-766, a PROTAC androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC)[J]. 2023.