Pinoresinol
产品说明书
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同义名 : | NSC 35444; (+)-Pinoresinol; (+)-Pinoresinol, NSC 35444 |
| CAS号 : | 487-36-5 | |
| 货号 : | A200331 | |
| 分子式 : | C20H22O6 | |
| 纯度 : | 99%+ | |
| 分子量 : | 358.39 | |
| MDL号 : | MFCD07784516 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(292.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides Oliver, may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C[3]. Pinoresinol (25 mg/kg, p.o.) ameliorated memory impairment in dementia model induced by cholinergic blockade in the passive avoidance test in a dose-dependent manner. Moreover, pinoresinol (50 μM) facilitated induction of hippocampal long-term potentiation, a cellular model of learning and memory. Pinoresinol blocked acetylcholinesterase (AchE), an acetylcholine-degrading enzyme, activity in a concentration-dependent manner. Moreover, pinoresinol (50 μM) facilitated calcium influx into neuro2a cell[4]. Oral administration of pinoresinol ameliorated Aβ-induced memory deficits without sensory dysfunction[5]. Pinoresinol attenuates inflammatory responses of microglia and could be potentially useful in modulation of inflammatory status in brain disorders[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01619020 | Healthy | Not Applicable | Completed | - | United States, Washington ... 展开 >> FHCRC Seattle, Washington, United States, 98109 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.79mL 0.56mL 0.28mL |
13.95mL 2.79mL 1.40mL |
27.90mL 5.58mL 2.79mL |
| 参考文献 |
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