Sotuletinib HCl

产品说明书

Print
Chemical Structure| 2222138-31-8 同义名 : BLZ945 hydrochloride
CAS号 : 2222138-31-8
货号 : A1977887
分子式 : C20H23ClN4O3S
纯度 : 99%+
分子量 : 434.94
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(241.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(229.92 mM)，配合低频超声助溶
生物活性
描述 Sotuletinib (BLZ945) hydrochloride acts as a potent, selective, and brain-penetrating inhibitor of CSF-1R (c-Fms), demonstrating an IC50 of 1 nM. It exhibits over 1,000-fold selectivity compared to its nearest receptor tyrosine kinase relatives[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.50mL

2.30mL

1.15mL

22.99mL

4.60mL

2.30mL
参考文献

[1]Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013 Oct;19(10):1264-72.

[2]Strachan DC, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968.