9-Aminoacridine
产品说明书
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同义名 : | 吖啶-9-胺 ;Aminacrine |
| CAS号 : | 90-45-9 | |
| 货号 : | A196593 | |
| 分子式 : | C13H10N2 | |
| 纯度 : | 98% | |
| 分子量 : | 194.23 | |
| MDL号 : | MFCD00037839 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(128.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 9-Aminoacridine, a fluorescent probe, is a pH indicator for quantitatively assessing transmembrane pH gradients, particularly in acidic environments. It possesses antimicrobial properties, effectively disrupting the proton motive force in K. pneumoniae by interacting with bacterial DNA. Additionally, 9-Aminoacridine acts as an inhibitor of HIV-1, blocking HIV LTR transcription in a manner highly dependent on the position and presence of its amino moiety. It also inhibits virus replication in HIV-1 infected cell lines and enhances the effectiveness of Rifampin in treating multidrug-resistant K. pneumoniae infections[1].[2].[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.15mL 1.03mL 0.51mL |
25.74mL 5.15mL 2.57mL |
51.49mL 10.30mL 5.15mL |
| 参考文献 |
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