Prinaberel

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Chemical Structure| 524684-52-4 同义名 : ERB-041
CAS号 : 524684-52-4
货号 : A195552
分子式 : C15H10FNO3
纯度 : 98%+
分子量 : 271.24
MDL号 : MFCD09954141
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(147.47 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Prinaberel (ERB-041) serves as a potent and selective agonist of estrogen receptor (ER) β, with IC50 values of 5.4, 3.1, and 3.7 nM for human, rat, and mouse ERβ, respectively. Prinaberel exhibits over 200-fold selectivity for ERβ over ERα. Furthermore, it acts as a potent chemopreventive agent for skin cancer by suppressing the WNT/β-catenin signaling pathway and inducing apoptosis in ovarian cancer cells[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.69mL

0.74mL

0.37mL

18.43mL

3.69mL

1.84mL

36.87mL

7.37mL

3.69mL
参考文献

[1]Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040.

[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.

[3]Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018