Iloprost

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Chemical Structure| 78919-13-8 同义名 : Ciloprost; ZK 36374; Iloprost, Endoprost, Ilomedin, Ciloprost, Ventavis, CHEMBL494; BAY Q6256; ZK 00036374
CAS号 : 78919-13-8
货号 : A195139
分子式 : C22H32O4
纯度 : 99%+
分子量 : 360.49
MDL号 : MFCD00867145
存储条件:

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(291.27 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

生物活性
描述 Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analog that plays a role in embryo development, reduces inflammation, and prevents tumor metastasis. It is applicable in studies related to peripheral vascular conditions[1].[2].[3].[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00887978 Pulmonary Hypertension Phase 3 Completed - -
NCT03610217 Scleroderma, Systemic ... 展开 >> Sclerosis, Systemic 收起 << Not Applicable Not yet recruiting October 2021 Canada, Ontario ... 展开 >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC    15196466332    Janet.Pope@sjhc.london.on.ca    Contact: Andreu Fernandez-Codina    151964661023    doccodina@gmail.com 收起 <<
NCT00380068 Pulmonary Hypertension Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.74mL

5.55mL

2.77mL

参考文献

[1]Kowalczyk-Zieba I, et al. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. 2020 Nov;157:286-296.

[2]Hildebrand M. Pharmacokinetics of iloprost and cicaprost in mice. Prostaglandins. 1992 Nov;44(5):431-42.

[3]Olave N, et al. Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L535-L544.

[4]Schneider MR, et al. Effects of prostacyclin analogues in in vivo tumor models. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:901-8.