Resminostat

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Chemical Structure| 864814-88-0 同义名 : RAS2410; 4SC-201
CAS号 : 864814-88-0
货号 : A193152
分子式 : C16H19N3O4S
纯度 : 98+%
分子量 : 349.4
MDL号 : MFCD18633257
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • HDAC3

    HDAC3, IC50:50.1 nM

  • HDAC6

    HDAC6, IC50:71.8 nM

  • HDAC1

    HDAC1, IC50:42.5 nM
描述 Resminostat is a potent inhibitor of HDAC1/3/6 (IC50=43-72 nM) and less potent to HDAC8 with IC50 of 877 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL
参考文献

[1]Mandl-Weber S, Meinel FG, et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol. 2010 May;149(4):518-28.

[2]J.E. Ang, et al. EJC Supplements, 2008, 6(12), 123-124.