WDR5-0102

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Chemical Structure| 824960-50-1 同义名 : -
CAS号 : 824960-50-1
货号 : A1921215
分子式 : C18H19ClN4O3
纯度 : 99%+
分子量 : 374.82
MDL号 : -
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(133.4 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 WDR5-0102 is an inhibitor targeting the WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). It suppresses MLL1 HMT activity but does not affect human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5 [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.34mL

2.67mL

1.33mL

26.68mL

5.34mL

2.67mL
参考文献

[1]Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2.