Otenabant HCl

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Chemical Structure| 686347-12-6 同义名 : CP 945598 Hydrochloride; CP 945,598 (hydrochloride); Otenabant; Otenabant Hydrochloride
CAS号 : 686347-12-6
货号 : A187051
分子式 : C25H26Cl3N7O
纯度 : 98+%
分子量 : 546.88
MDL号 : MFCD18251544
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • CB1

    rCB1, Ki:2.8 nM

    hCB1, Ki:0.7 nM
描述 Otenabant hydrochloride is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.14mL

1.83mL

0.91mL

18.29mL

3.66mL

1.83mL
参考文献

[1]Hadcock JR, Griffith DA, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.

[2]Griffith DA, Hadcock JR, et al. Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J Med Chem. 2009 Jan 22;52(2):234-7.