PCSK9-IN-10

产品说明书

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Chemical Structure| 368434-98-4 同义名 : -
CAS号 : 368434-98-4
货号 : A1868760
分子式 : C18H23N5O4
纯度 : 99%+
分子量 : 373.41
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(669.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 PCSK9-IN-10 is a potent and orally active PCSK9 inhibitor with an IC50 value of 6.4 µM. PCSK9-IN-10 enhances the expression of LDLR protein while reducing PCSK9 expression. PCSK9-IN-10 demonstrates efficacy in reducing the progression of atherosclerosis and holds promise for research on hyperlipidemia [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.39mL

2.68mL

1.34mL

26.78mL

5.36mL

2.68mL
参考文献

[1]Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2022 Dec 26;247:115047.