SR9009

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Chemical Structure| 1379686-30-2 同义名 : REV-ERB Agonist II
CAS号 : 1379686-30-2
货号 : A183954
分子式 : C20H24ClN3O4S
纯度 : 99%
分子量 : 437.94
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(239.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism.
作用机制 SR-9009 directly binds to REV-ERB-α.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.42mL

2.28mL

1.14mL

22.83mL

4.57mL

2.28mL
参考文献

[1]Solt LA, Wang Y, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012 Mar 29;485(7396):62-8.

[2]Dierickx P, Emmett MJ, et al. SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12147-12152.