同义名 :	D-Borneol; (+)-Borneol; (+)-endo-Borneol; (1R)-(+)-Borneol
	CAS号 :	464-43-7
	货号 :	A182769
	分子式 :	C10H18O
	纯度 :	98%
	分子量 :	154.25
	MDL号 :	MFCD00066427
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-

生物活性

描述

(+)-Borneol, a bicyclic monoterpene found in many plants, has many biological activities. In vitro studies, (+)-borneol could improve cell cytotoxicity induced by β-amyloid in human neuroblastoma cells through decreasing reactive oxygen species generation and increasing B-cell lymphoma 2 (Bcl-2) expression. Besides this, it was found that (+)-borneol could depress p-glycoprotein on brain microvascular endothelial cells via medicating the NF-κB pathway. In vivo studies, (+)-borneol could contribute to the improvement of fear and anxiety in rats possibly by modulation of the GABAergic neurotransmission. In addition, (+)-borneol has the ability of strengthening the efficacy of edaravone against DSS-induced colitis in rats.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	6.48mL 1.30mL 0.65mL	32.41mL 6.48mL 3.24mL	64.83mL 12.97mL 6.48mL

参考文献

[1]Cao B, Ni HY, et al. (+)-Borneol suppresses conditioned fear recall and anxiety-like behaviors in mice. Biochem Biophys Res Commun. 2018;495(2):1588-1593. [2]Hur J, Pak SC, et al. Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells. Pharm Biol. 2013;51(1):30-5. [3]Fan X, Chai L, et al. Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model. Int J Mol Sci. 2015;16(11):27576-88. [4]Zhang X, Xu F, et al. (+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway. Int Immunopharmacol. 2017.