Escitalopram oxalate

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Chemical Structure| 219861-08-2 同义名 : 依他普仑草酸盐;草酸艾司西酞普兰 ;(S)-(+)-Citalopram oxalate; Cytalopram; Citalopram; UNII-5U85DBW7LO; 219861-08-2; Lexapro; Cipralex; (S)-Citalopram oxalate
CAS号 : 219861-08-2
货号 : A182166
分子式 : C22H23FN2O5
纯度 : 97%
分子量 : 414.43
MDL号 : MFCD06407826
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 14 mg/mL(33.78 mM)
生物活性
靶点

  • 5-HT

    5-HT, Ki:0.89 nM
描述 Escitalopram oxalate, the S-enantiomer of racemic citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. It has approximately 30 times higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both the dopamine and norepinephrine transporters. Escitalopram oxalate is used in the study of major depression[1][2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00668525 Major Depressive Disorder Phase 3 Completed - -
NCT00668525 - Completed - -
NCT01398514 Fear Conditioning Phase 4 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.13mL

4.83mL

2.41mL
参考文献

[1]Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21.

[2]Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8.

[3]Wu C , et al. Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiol Aging. 2018;67:137-147.

[4]Cirrito JR, et al. Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. 2020;95(19):e2666-e2674.