Isotretinoin

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Chemical Structure| 4759-48-2 同义名 : 13-顺-视黄酸 ;13-cis-Retinoic acid; AGN 190013; Zenatane; Myorisan; Accutane; 13-cis-Vitamin A Acid; 13(Z)-Retinoic Acid
CAS号 : 4759-48-2
货号 : A181906
分子式 : C20H28O2
纯度 : 98% HPLC
分子量 : 300.44
MDL号 : MFCD00079542
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(349.49 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Isotretinoin (13-cis-Retinoic acid) is an orally active derivative of vitamin A commonly used in the treatment of severe acne. It also exhibits anticancer activity[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.64mL

3.33mL

1.66mL

33.28mL

6.66mL

3.33mL
参考文献

[1]Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1(3):162-9.

[2]Dahl AR, et al. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6(8):3015-24

[3]Bergoli RD, et al. Isotretinoin effect on alveolar repair after exodontia--a study in rats. Oral Maxillofac Surg. 2011 Jun;15(2):85-92.

[4]Ramírez-Flores PN, et al. Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells. Molecules. 2021 Sep 22;26(19):5742.