Clazosentan

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Chemical Structure| 180384-56-9 同义名 : Ro 61-1790; VML 588; AXV-343434; AXV034; AXV-034343
CAS号 : 180384-56-9
货号 : A181836
分子式 : C25H23N9O6S
纯度 : 98+%
分子量 : 577.57
MDL号 : MFCD20040418
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(147.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.66mL

1.73mL

0.87mL

17.31mL

3.46mL

1.73mL
参考文献

[1]Fujimura M, Joo JY, et al. Preventive Effect of Clazosentan against Cerebral Vasospasm after Clipping Surgery for Aneurysmal Subarachnoid Hemorrhage in Japanese and Korean Patients. Cerebrovasc Dis. 2017 May 3;44(1-2):59-67.

[2]Wong GK, Poon WS. Clazosentan for patients with subarachnoid haemorrhage: lessons learned. Lancet Neurol. 2011 Oct;10(10):871; author reply 871-2.