F5446

产品说明书

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Chemical Structure| 2304465-89-0 同义名 : -
CAS号 : 2304465-89-0
货号 : A1817062
分子式 : C26H17ClN2O8S
纯度 : 99%+
分子量 : 552.94
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(189.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 F5446 is an inhibitor of SUV39H1 methyltransferase. It induces cell death in human colon carcinoma cells in a dose-dependent manner[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.04mL

1.81mL

0.90mL

18.09mL

3.62mL

1.81mL
参考文献

[1]Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.