CAY10746

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Chemical Structure| 2247240-76-0 同义名 : -
CAS号 : 2247240-76-0
货号 : A1806913
分子式 : C26H23N3O5
纯度 : 98%
分子量 : 457.48
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(185.8 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 CAY10746 is a selective Rho kinase (ROCK) inhibitor, displaying inhibitory activity towards ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively, and is researched for its potential in treating diabetic retinopathy (DR) [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.93mL

2.19mL

1.09mL

21.86mL

4.37mL

2.19mL
参考文献

[1]Lanying Zhao, et al. Discovery of 4 H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models. J Med Chem. 2019 Dec 12;62(23):10691-10710.