C-DIM12

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Chemical Structure| 178946-89-9 同义名 : 4-Chlorophenyl-3,3'-diindolylmethane; DIM-C-pPhCl
CAS号 : 178946-89-9
货号 : A179040
分子式 : C23H17ClN2
纯度 : 99%+
分子量 : 356.85
MDL号 : MFCD05625919
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(294.24 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 C-DIM12 is characterized as a potent and orally efficacious antagonist of Nurr1, known for suppressing tumor proliferation and autophagy while promoting cell apoptosis. It exhibits both anti-inflammatory and neuroprotective properties, making it suitable for research in cancer and neurological disorders. Through its actions, C-DIM12 mitigates tumor growth and cellular self-digestion processes and encourages cell programmed death, contributing to its utility in scientific investigations related to oncology and neurology1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.80mL

0.56mL

0.28mL

14.01mL

2.80mL

1.40mL

28.02mL

5.60mL

2.80mL
参考文献

[1]Zarei M, et al. Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Cancer Res Commun. 2021;1(2):65-78.

[2]Sean L. Hammond, et al. The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J Pharmacol Exp Ther. 2018 Jun; 365(3): 636–651.

[3]Keita Kinoshita, et al. A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice. Sci Rep. 2022; 12: 11009.