5-Iodotubercidin
产品说明书
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同义名 : | 5-碘代杀结核菌素 ;NSC 113939; 5-ITu; Itu |
| CAS号 : | 24386-93-4 | |
| 货号 : | A177991 | |
| 分子式 : | C11H13IN4O4 | |
| 纯度 : | 98% | |
| 分子量 : | 392.15 | |
| MDL号 : | MFCD00055131 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(63.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin facilitates glycogen synthesis in isolated hepatocytes by deactivating phosphorylase and activating glycogen synthase. Furthermore, 5-Iodotubercidin obstructs the activity of several kinases including CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin[1].[2].[3]. | ||
| 作用机制 | 5-iodotubercidin increases the release of adenosine from hypoxic/hypoglycemic hippocampal slices[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.55mL 0.51mL 0.26mL |
12.75mL 2.55mL 1.27mL |
25.50mL 5.10mL 2.55mL |
| 参考文献 |
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