SP-2509

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Chemical Structure| 1423715-09-6 同义名 : -
CAS号 : 1423715-09-6
货号 : A177360
分子式 : C19H20ClN3O5S
纯度 : 98+%
分子量 : 437.9
MDL号 : MFCD28348370
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(79.93 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • KDM1

    LSD1, IC50:13 nM
描述 SP2509 acts as a potent, selective inhibitor of lysine specific demethylase 1 (LSD1), with an IC50 of 13 nM[1].
作用机制 SP2509 attenuated the binding of LSD1 with the corepressor CoREST, increased the permissive H3K4Me3 mark on the target gene promoters.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.42mL

2.28mL

1.14mL

22.84mL

4.57mL

2.28mL
参考文献

[1]Fiskus W, et al. Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia. 2014 Nov;28(11):2155-64.

[2]Inui K, et al. Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target. Protein Sci. 2017 Feb 20