FPS-ZM1

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Chemical Structure| 945714-67-0 同义名 : -
CAS号 : 945714-67-0
货号 : A171795
分子式 : C20H22ClNO
纯度 : 98%
分子量 : 327.85
MDL号 : MFCD22378757
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(320.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 FPS-ZM1 demonstrates a higher affinity for inhibiting Aβ/RAGE binding in CHO cells, nearly doubling the effectiveness compared to its precursor, FPS2. It also prevents the binding of other RAGE ligands, such as S100 calcium-binding protein B and amphoterin. FPS-ZM1 surpasses FPS2 in mitigating the Aβ40-triggered elevation of BACE1 mRNA and protein levels, as well as the production of sAPPβ, a cleavage product of APP by BACE1, indicating BACE1 enzymatic activity[1].
作用机制 FPS-ZM1 specifically binds to the V domain of RAGE to block Aβ/RAGE interaction, inhibiting Aβ-induced cellular stress in vitro and in vivo.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.25mL

3.05mL

1.53mL

30.50mL

6.10mL

3.05mL
参考文献

[1]Deane R, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr;122(4):1377-92.

[2]Hong Y, et al. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res. 2016 May;41(5):1192-9.