Direct Blue 1

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Chemical Structure| 2610-05-1 同义名 : Chicago Sky Blue 6B; C.I. 24410; NCI 9617; CSB6B; Chicago Skye Blue 6B; Pontamine sky blue
CAS号 : 2610-05-1
货号 : A167714
分子式 : C34H24N6Na4O16S4
纯度 : Dye content 50%
分子量 : 992.8
MDL号 : MFCD00004020
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(120.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(2.01 mM)，配合低频超声助溶
生物活性
描述 Direct Blue 1, known as Chicago Sky Blue 6B, is employed to quench background autofluorescence in immunofluorescence histochemistry. It acts as a potent and competitive inhibitor of VGLUT and can block the binding of Aβ to small molecule PrP ligands. Direct Blue 1 exhibits anti-inflammatory properties[1][2][3][4][5][6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.01mL

0.20mL

0.10mL

5.04mL

1.01mL

0.50mL

10.07mL

2.01mL

1.01mL
参考文献

[1]Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344.

[2]Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658.

[3]Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

[4]Min JO, et al. Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. Mol Brain. 2022 Mar 28;15(1):27.

[5]Jin K, et al. Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway. Biochem Pharmacol. 2021 Oct;192:114734.

[6]He Z, et al. Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. Behav Brain Res. 2013 Feb 15;239:172-6.