GPR52 antagonist-1

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Chemical Structure| 1239987-91-7 同义名 : GPR52 Comp-43; GPR52-IN-43; Comp-43
CAS号 : 1239987-91-7
货号 : A1671439
分子式 : C15H14OS
纯度 : 99%+
分子量 : 242.34
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1031.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 GPR52 antagonist-1 is a GPR52 antagonist with an IC50 of 0.63 μM, which reduces mutant huntingtin protein (mHTT) levels by targeting GPR52 and enhances the survival of mouse primary striatal neurons[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.13mL

0.83mL

0.41mL

20.63mL

4.13mL

2.06mL

41.26mL

8.25mL

4.13mL
参考文献

[1]Wang C, et al. GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes. J Med Chem. 2021 Jan 28;64(2):941-957.