ANO1-IN-1

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Chemical Structure| 407587-01-3 同义名 : -
CAS号 : 407587-01-3
货号 : A1671166
分子式 : C18H28N2O2S
纯度 : 99%+
分子量 : 336.49
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(742.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ANO1-IN-1, a selective ANO1 channel blocker, exhibits IC50 values of 2.56 μM for ANO1 and 15.43 μM for ANO2, significantly reducing proliferation of glioblastoma cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.86mL

2.97mL

1.49mL

29.72mL

5.94mL

2.97mL
参考文献

[1]Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.