Tildacerfont

产品说明书

Print
Chemical Structure| 1014983-00-6 同义名 : SPR001; LY2371712
CAS号 : 1014983-00-6
货号 : A1671111
分子式 : C20H26ClN5OS
纯度 : 99%+
分子量 : 419.97
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(21.43 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Tildacerfont is a potent, orally active CRF1 receptor antagonist. Tildacerfont is effective in reducing ACTH and adrenal androgen levels. Tildacerfont has a favourable safety profile and can be used to study congenital adrenal hyperplasia[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.91mL

2.38mL

1.19mL

23.81mL

4.76mL

2.38mL
参考文献

[1]Prete A, et al. Clinical advances in the pharmacotherapy of congenital adrenal hyperplasia. Eur J Endocrinol. 2021;186(1):R1-R14. Published 2021 Nov 30.