BI-78D3

产品说明书

Print
Chemical Structure| 883065-90-5 同义名 : JNK Inhibitor X; c-Jun N-terminal Kinase Inhibitor X
CAS号 : 883065-90-5
货号 : A166355
分子式 : C13H9N5O5S2
纯度 : 99%+
分子量 : 379.37
MDL号 : MFCD01313575
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(276.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • JNK1

    JNK, IC50:280 nM

  • JNK

    JNK, IC50:280 nM

  • JNK2

    JNK, IC50:280 nM

  • JNK3

    JNK, IC50:280 nM
描述 BI-78D3 is a competitive JNK inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.18mL

2.64mL

1.32mL

26.36mL

5.27mL

2.64mL
参考文献

[1]Posthumadeboer J, van Egmond PW, et al. Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. Oncotarget. 2012 Oct;3(10):1169-81.

[2]Stebbins JL, De SK, et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13.