D-AP5

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Chemical Structure| 79055-68-8 同义名 : D-APV; D-2-Amino-5-phosphonovaleric acid
CAS号 : 79055-68-8
货号 : A166104
分子式 : C5H12NO5P
纯度 : 99%+
分子量 : 197.13
MDL号 : MFCD00078839
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 2 mg/mL(10.15 mM)，配合低频超声助溶
生物活性
描述 D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 inhibits the glutamate binding site of NMDA receptors[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.07mL

1.01mL

0.51mL

25.36mL

5.07mL

2.54mL

50.73mL

10.15mL

5.07mL
参考文献

[1]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75.

[2]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.

[3]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.