NSC45586 sodium

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Chemical Structure| 6300-44-3 同义名 : NSC45586
CAS号 : 6300-44-3
货号 : A1615366
分子式 : C20H17N6NaO3
纯度 : 98%+
分子量 : 412.38
MDL号 : MFCD33029321
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 5 mg/mL(12.12 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 As a PHLPP phosphatase inhibitor, NSC45586 sodium acts on the pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP), specifically targeting the PP2C domain within PHLPP1 and PHLPP2, thereby inducing AKT activation in neuronal cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.12mL

2.42mL

1.21mL

24.25mL

4.85mL

2.42mL
参考文献

[1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.