Tpl2 Kinase Inhibitor 1

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Chemical Structure| 871307-18-5 同义名 : c-Cot Kinase Inhibitor; Tumor Progression Locus 2 Kinase Inhibitor; TC-S 7006; MAP3K8 Kinase Inhibitor; Tpl2 Kinase Inhibitor
CAS号 : 871307-18-5
货号 : A160473
分子式 : C21H14ClFN6
纯度 : 95%
分子量 : 404.83
MDL号 : MFCD10566771
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(259.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Tpl2 Kinase Inhibitor 1, a 3-pyridylmethylamino analog, selectively inhibits Tpl2 (IC50=50 nM), encompassing COT kinase and MAP3K8. It significantly contributes to controlling inflammation and the advancement of certain cancers[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.35mL

2.47mL

1.24mL

24.70mL

4.94mL

2.47mL
参考文献

[1]Gavrin LK, et al. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.

[2]Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.