ML254

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Chemical Structure| 1428630-86-7 同义名 : -
CAS号 : 1428630-86-7
货号 : A1602022
分子式 : C18H15FN2O2
纯度 : 98%+
分子量 : 310.32
MDL号 : MFCD28386364
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(338.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ML254 stands out as a significant potentiator of mGlu5, featuring an EC50 and pEC50 of 9.3 nM and 8.03 nM in rat mGlu5, respectively. This property renders it a valuable tool for schizophrenia research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.11mL

3.22mL

1.61mL

32.22mL

6.44mL

3.22mL
参考文献

[1]Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J Med Chem. 2013;56(20):7976-7996.