HS-243

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Chemical Structure| 848249-10-5 同义名 : -
CAS号 : 848249-10-5
货号 : A1598756
分子式 : C17H16N4O3
纯度 : 95%
分子量 : 324.33
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(123.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 HS-243 is a potent and selective inhibitor of IRAK-4 and IRAK-1, with IC50 values of 20 nM and 24 nM, respectively. It exhibits minimal inhibition of TAK1 (transforming growth factor β-activated kinase 1), with an IC50 of 0.5 µM. HS-243 demonstrates anti-inflammatory and anticancer properties[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.42mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL
参考文献

[1]Scarneo SA, et al. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. J Biol Chem. 2020 Feb 7;295(6):1565-1574.