PRN1371

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Chemical Structure| 1802929-43-6 同义名 : -
CAS号 : 1802929-43-6
货号 : A157519
分子式 : C26H30Cl2N6O4
纯度 : 99%
分子量 : 561.46
MDL号 : MFCD31560471
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(44.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • FGFR2

    FGFR2, IC50:1.3 nM

  • FGFR3

    FGFR3, IC50:4.1 nM

  • FGFR4

    FGFR4, IC50:19.3 nM

  • FGFR1

    FGFR1, IC50:0.6 nM
描述 PRN1371 is an irreversible covalent FGFR inhibitor used for the treatment of solid tumor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.91mL

1.78mL

0.89mL

17.81mL

3.56mL

1.78mL
参考文献

[1]Brameld KA, Owens TD, et al. Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d] pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors. J Med Chem. 2017 Jun 30.