Potassium Oxonate
产品说明书
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同义名 : | Potassium azaorotate; Potassium otastat; Oxonate, potassium; Oxonic acid potassium salt; Allantoxanic Acid; Oxonic Acid (potassium salt); Oteracil potassium |
| CAS号 : | 2207-75-2 | |
| 货号 : | A157215 | |
| 分子式 : | C4H2KN3O4 | |
| 纯度 : | 98% | |
| 分子量 : | 195.17 | |
| MDL号 : | MFCD00010565 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 3 mg/mL(15.37 mM)，配合低频超声，并水浴加热至45℃助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Potassium oxonate is a uricase inhibitor, affecting the phosphorylation of 5-FU into 5-fluorouridine-5'-monophosphate differently from allopurinol, both in cell-free extracts and intact cells. When administered orally alongside 5-FU (2 mg/kg) to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) specifically inhibits the conversion of 5-FU into its phosphorylated form and its incorporation into RNA in the intestines but not in tumor or bone marrow tissues[1]. Additionally, an oxonic acid diet raises plasma uric acid levels by 80-90 micromol/L, with an observed increase in blood pressure only in hyperuricemic rats subjected to a 5/6 nephrectomy (18 mmHg)[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.12mL 1.02mL 0.51mL |
25.62mL 5.12mL 2.56mL |
51.24mL 10.25mL 5.12mL |
| 参考文献 |
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