Adarotene

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Chemical Structure| 496868-77-0 同义名 : ST1926
CAS号 : 496868-77-0
货号 : A156326
分子式 : C25H26O3
纯度 : 99%+
分子量 : 374.47
MDL号 : MFCD05861282
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(66.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Adarotene is an effective apoptosis inducer and surprisingly produced DNA damage. ST1926 exhibites a potent antiproliferative activity on a large panel of human tumor cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.35mL

2.67mL

1.34mL

26.70mL

5.34mL

2.67mL
参考文献

[1]Garattini E, Parrella E, et al. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.

[2]Cincinelli R, Dallavalle S, et al. A novel atypical retinoid endowed with proapoptotic and antitumor activity. J Med Chem. 2003 Mar 13;46(6):909-12.