VX-150

产品说明书

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Chemical Structure| 1793080-72-4 同义名 : EOS-62073
CAS号 : 1793080-72-4
货号 : A1549079
分子式 : C21H17F4N2O7P
纯度 : 99%+
分子量 : 516.34
MDL号 : MFCD34184505
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(232.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 VX-150 is an orally active, highly selective NaV1.8 inhibitor with potential for researching various pain indications [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.94mL

0.39mL

0.19mL

9.68mL

1.94mL

0.97mL

19.37mL

3.87mL

1.94mL
参考文献

[1]Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826.