GRK5-IN-2

产品说明书

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Chemical Structure| 1642839-27-7 同义名 : -
CAS号 : 1642839-27-7
货号 : A1547307
分子式 : C20H20N4O4
纯度 : 98%
分子量 : 380.4
MDL号 : MFCD34470578
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(157.73 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 GRK5-IN-2, a pyridine-based bicyclic compound, acts as a potent inhibitor of G-protein-coupled receptor kinase 5 (GRK5). It modulates the expression and/or release of insulin, making it valuable for research into metabolic diseases[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.14mL

2.63mL

1.31mL

26.29mL

5.26mL

2.63mL
参考文献

[1]Axel Ullrich (Prof. Dr.), et al. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators. EP2818472A1.