NF-κΒ activator 1

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Chemical Structure| 2387524-59-4 同义名 : Compound 32
CAS号 : 2387524-59-4
货号 : A1543063
分子式 : C16H11FN2O2S
纯度 : 99%+
分子量 : 314.33
MDL号 : MFCD33023225
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(334.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NF-κΒ activator 1 is a potent activator of NF-κΒ with an EC50 of 0.9 μM. It induces the expression of superoxide dismutase (SOD)2 mRNA[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.91mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL
参考文献

[1]Mathew B, et al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952.