Narmafotinib

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Chemical Structure| 1393653-34-3 同义名 : AMP-945
CAS号 : 1393653-34-3
货号 : A1535395
分子式 : C28H32F3N5O2
纯度 : 99%
分子量 : 527.58
MDL号 : MFCD34604148
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(199.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Narmafotinib (AMP-945) is a potent inhibitor of focal adhesion kinase (FAK) with a dissociation constant (KD) of 0.21 nM. It inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC50 of 7 nM and exhibits low overall cellular toxicity, with an IC50 of 2.7 µM in MDA-MB-231 cells[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.48mL

1.90mL

0.95mL

18.95mL

3.79mL

1.90mL
参考文献

[1]Street I, et al. Abstract LB-308: combination of CTx-0294945 a highly selective inhibitor of focal adhesion kinase with bevacizumab in pre-clinical models of breast cancer[J]. Cancer Research, 2012, 72(8_Supplement): LB-308-LB-308.

[2]Amplia Therapeutics completes single-dose study of AMP945