ARN-21934

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Chemical Structure| 2230854-93-8 同义名 : -
CAS号 : 2230854-93-8
货号 : A1534057
分子式 : C21H24N6
纯度 : 98%+
分子量 : 360.46
MDL号 : MFCD34179494
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(19.42 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ARN-21934 is a highly selective, blood-brain barrier (BBB) penetrant inhibitor of human topoisomerase II α over β. It inhibits DNA relaxation with an IC50 of 2 μM compared to Etoposide (IC50=120 μM). ARN-21934 demonstrates favorable in vivo pharmacokinetics and holds promise as a lead compound for anticancer research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.74mL

5.55mL

2.77mL
参考文献

[1]Jose Antonio Ortega, et al. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020 Nov 12;63(21):12873-12886.