MRT-81

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Chemical Structure| 1263132-08-6 同义名 : -
CAS号 : 1263132-08-6
货号 : A1532009
分子式 : C31H29N3O5S
纯度 : 95%
分子量 : 555.64
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(188.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MRT-81 is a strong antagonist of human and rodent smoothened (Smo) receptors, exhibiting an IC50 value of 41 nM in Shh-light2 cells and demonstrating potent hedgehog pathway inhibition. MRT-81 is utilized in cancer research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

9.00mL

1.80mL

0.90mL

18.00mL

3.60mL

1.80mL
参考文献

[1]Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012 Feb 23;55(4):1559-71.