Protocatechualdehyde

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Chemical Structure| 139-85-5 同义名 : 3,4-二羟基苯甲醛 ;Catechaldehyde; Protocatechuic aldehyde; NSC 22961; 3,4-Dihydroxybenzaldehyde; Rancinamycin IV
CAS号 : 139-85-5
货号 : A152308
分子式 : C7H6O3
纯度 : 98%
分子量 : 138.12
MDL号 : -
存储条件：

Pure form Keep in dark place, sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(362 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 3,4-Dihydroxybenzaldehyde, a phenolic acid compound, has many biological activities. In vitro studies, 3,4-dihydroxybenzaldehyde could improve the oxidative DNA damage and apoptosis induced by hydrogen peroxide [1] . Besides this, 3,4-dihydroxybenzaldehyde also contributes to the inhibition of protein kinase CKII activity [2] . In vivo studies, it was found that 3,4-dihydroxybenzaldehyde could ameliorate cerebral ischemia-reperfusion-induced oxidative injury and have neuroprotective effect through the PKCε/Nrf2/HO-1 pathway in Sprague-Dawley rats [3] . In addition, 3,4-dihydroxybenzaldehyde also has the ability of relieving symptoms of sepsis induced by caecal ligation and puncture (CLP) in rats [4] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.24mL

1.45mL

0.72mL

36.20mL

7.24mL

3.62mL

72.40mL

14.48mL

7.24mL
参考文献

[1]Jeong JB, Hong SC, Jeong HJ. 3,4-dihydroxybenzaldehyde purified from the barley seeds (Hordeum vulgare) inhibits oxidative DNA damage and apoptosis via its antioxidant activity. Phytomedicine. 2009;16(1):85-94.

[2]Lee BH, Yoon SH, et al. Apoptotic cell death through inhibition of protein kinase CKII activity by 3,4-dihydroxybenzaldehyde purified from Xanthium strumarium. Nat Prod Res. 2008;22(16):1441-50.

[3]Guo C, Wang S, et al. Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway. Mol Neurobiol. 2017;54(2):833-845.

[4]Xu Y, Jiang WL, et al. Protocatechuic aldehyde protects against experimental sepsis in vitro and in vivo. Basic Clin Pharmacol Toxicol. 2012;110(4):384-9.