4-Phenylbutyric acid
产品说明书
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同义名 : | 苯丁酸 ;4-PBA; Benzenebutyric acid |
| CAS号 : | 1821-12-1 | |
| 货号 : | A148817 | |
| 分子式 : | C10H12O2 | |
| 纯度 : | 98% | |
| 分子量 : | 164.2 | |
| MDL号 : | MFCD00004403 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(639.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 2 mg/mL(12.18 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | 4-Phenylbutyric acid (4-PBA), known as an inhibitor of histone deacetylases (HDAC), effectively inhibits the growth of non-small cell lung cancer (NSCLC) cell lines at a concentration of 2 mM. When combined with ciglitizone, 4-Phenylbutyric acid further enhances the growth arrest of cancer cells[1]. Additionally, 4-Phenylbutyric acid, at concentrations ranging from 0 to 5 mM, dose-dependently inhibits African swine fever virus (ASFV) infection. 4-Phenylbutyric acid also disrupts ASFV-induced hypoacetylation of histone H3 at lysines 9 and 14 and inhibits late protein synthesis by the virus. The synergistic effect of 4-Phenylbutyric acid with enrofloxacin significantly eliminates ASFV replication[2]. The introduction of bafilomycin A1 leads to an increase in the accumulation of LC3II, a marker for autophagy, whereas 4-Phenylbutyric acid (4-PBA) substantially reduces this buildup. Lipopolysaccharide (LPS) lowers p62 levels, a process that is reversed by Benzenebutyric acid after 48 hours of LPS stimulation. Furthermore, while LPS increases the percentage of cells with acidotic vesicular organelles (AVOs) at 48 hours, 4-Phenylbutyric acid significantly lowers this percentage. Specifically, treatment with Benzenebutyric acid reduces the percentage of cells with AVOs from 61.6% to 53.1%, indicating that 4-Phenylbutyric acid inhibits LPS-induced autophagy[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.09mL 1.22mL 0.61mL |
30.45mL 6.09mL 3.05mL |
60.90mL 12.18mL 6.09mL |
| 参考文献 |
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