(S)-Sunvozertinib
产品说明书
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同义名 : | (S)-DZD9008; DZD9008; Sunvozertinib |
| CAS号 : | 2370013-49-1 | |
| 货号 : | A1487538 | |
| 分子式 : | C29H35ClFN7O3 | |
| 纯度 : | 99% | |
| 分子量 : | 584.08 | |
| MDL号 : | MFCD34603702 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(85.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 靶点 |
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| 描述 | (S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib), exhibits inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation, and Her2 exon20 YVMA insertion (with IC50 values of 51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). Additionally, (S)-Sunvozertinib inhibits BTK[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.71mL 0.34mL 0.17mL |
8.56mL 1.71mL 0.86mL |
17.12mL 3.42mL 1.71mL |
| 参考文献 |
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