LJ001

产品说明书

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Chemical Structure| 851305-26-5 同义名 : -
CAS号 : 851305-26-5
货号 : A1483473
分子式 : C17H13NO2S2
纯度 : 98%+
分子量 : 327.42
MDL号 : -
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(320.69 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LJ001 is a versatile and orally active antiviral agent known for its broad-spectrum activity. It operates by binding to viral membranes, effectively inhibiting infections such as TGEV (transmissible gastroenteritis virus) and PDCoV (porcine deltacoronavirus), and reducing the expression of their respective N-proteins[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.27mL

3.05mL

1.53mL

30.54mL

6.11mL

3.05mL
参考文献

[1]Zhang Y, et al. Rhodanine derivative LJ001 inhibits TGEV and PDCoV replication in vitro. Virus Res. 2020 Nov;289:198167.

[2]Wolf MC, et al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62.