Zinc pyrithione

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Chemical Structure| 13463-41-7 同义名 : 2-巯基吡啶-N-氧化物 锌盐;吡硫锌;1-羟基吡啶-2-硫酮锌 ;OM-1563
CAS号 : 13463-41-7
货号 : A1477298
分子式 : C10H8N2O2S2Zn
纯度 : 98+%
分子量 : 317.72
MDL号 : MFCD00067336
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(110.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Proton Pump
描述 Zinc Pyrithione is an antifungal and antibacterial agent by disrupting membrane transport through blocking the proton pump[1]. Zinc Pyrithione is also a copper ionophore, facilitating the transport of copper ions into cells, which is beneficial for studying cuproptosis[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.31mL

15.74mL

3.15mL

1.57mL

31.47mL

6.29mL

3.15mL
参考文献

[1]Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.

[2]Peter Tsvetkov, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375(6586):1254-1261.