DCH36_06

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Chemical Structure| 593273-05-3 同义名 : -
CAS号 : 593273-05-3
货号 : A1475535
分子式 : C18H13ClN2O3S
纯度 : 97%
分子量 : 372.83
MDL号 : MFCD03864746
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(321.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 DCH36_06, a potent and selective p300/CBP inhibitor, exhibits IC50s of 0.6 μM for p300 and 3.2 μM for CBP. It induces hypoacetylation of H3K18 in leukemic cells and demonstrates anti-tumor activity [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.41mL

2.68mL

1.34mL

26.82mL

5.36mL

2.68mL
参考文献

[1]Wenchao Lu, et al. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407.