UNC6852

产品说明书

Print
Chemical Structure| 2688842-08-0 同义名 : -
CAS号 : 2688842-08-0
货号 : A1467813
分子式 : C43H48N10O6S
纯度 : 98%
分子量 : 832.97
MDL号 : MFCD32701932
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(126.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • bromodomain

    EED, IC50:247 nM
描述 UNC6852, a selective degrader of the polycomb repressive complex 2 (PRC2) employing PROTAC technology, incorporates an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, exhibiting an IC50 of 247 nM for EED[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.20mL

0.24mL

0.12mL

6.00mL

1.20mL

0.60mL

12.01mL

2.40mL

1.20mL
参考文献

[1]Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.