TD-165

产品说明书

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Chemical Structure| 2305936-56-3 同义名 : -
CAS号 : 2305936-56-3
货号 : A1467734
分子式 : C46H59N7O8S
纯度 : 98%
分子量 : 870.07
MDL号 : -
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(57.47 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 TD-165 is a cereblon (CRBN) degrader utilizing PROTAC technology. It consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.15mL

0.23mL

0.11mL

5.75mL

1.15mL

0.57mL

11.49mL

2.30mL

1.15mL
参考文献

[1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654.