CA77.1

产品说明书

Print
Chemical Structure| 2412270-22-3 同义名 : CA
CAS号 : 2412270-22-3
货号 : A1463916
分子式 : C16H12ClN3O
纯度 : 99%+
分子量 : 297.74
MDL号 : N/A
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(13.43 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CA77.1 is a potent, brain-penetrant, and orally active activator of chaperone-mediated autophagy (CMA) with favorable pharmacokinetics. A derivative of AR7, CA77.1 enhances the expression of the lysosomal receptor LAMP2A in lysosomes. It ameliorates behavior and neuropathology in the PS19 mouse model, making it useful for Alzheimer's disease research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.79mL

3.36mL

1.68mL

33.59mL

6.72mL

3.36mL
参考文献

[1]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell. 2021 May 13;184(10):2696-2714.e25.